Figure. A polypeptide (PCys2n)-based detoxification system for cisplatin (CDDP) that follows the 2-step administration principle. Reprinted with permission from ; copyright (2022) John Wiley & Sons.Since 2010, there has been a much greater awareness of the problem of intoxication, which has become the most common form of accidental and intentional death. In 2020, more than 90,000 people died of intoxication in the United States, which surpassed deaths due to motor vehicle accidents and firearms use to become the leading external cause of mortality. For clinical context, the causes of intoxication could be divided into 3 categories: (a) accidental ingestion of unknown xenobiotics, (b) excessive ingestion of bioactive molecules, and (c) inevitable toxicity arising from highly toxic medical drugs. However, the limited role of nonspecific extracorporeal techniques and the finite number of well-established antidotes are incapable of dealing with the complex emergencies arising from various forms of intoxication. Considering the modular properties of biocompatibility, binding affinity, biodistribution profile, and circulation time required to constitute a detoxification system, nanoantidotes would form a superior detoxification system more applicable to clinical practice .